Bacteria in cancer initiation, promotion and progression

G El Tekle, WS Garrett - Nature Reviews Cancer, 2023 - nature.com
Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …

Microbiota in health and diseases

K Hou, ZX Wu, XY Chen, JQ Wang, D Zhang… - Signal transduction and …, 2022 - nature.com
The role of microbiota in health and diseases is being highlighted by numerous studies
since its discovery. Depending on the localized regions, microbiota can be classified into …

Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis

F Cao, L **, Y Gao, Y Ding, H Wen, Z Qian… - Nature …, 2023 - nature.com
Inflammatory bowel disease can be caused by the dysfunction of the intestinal mucosal
barrier and dysregulation of gut microbiota. Traditional treatments use drugs to manage …

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

M Zepeda-Rivera, SS Minot, H Bouzek, H Wu… - Nature, 2024 - nature.com
Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely
found in the lower gastrointestinal tract of healthy individuals, is enriched in human …

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

JL Galeano Niño, H Wu, KD LaCourse… - Nature, 2022 - nature.com
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment
across human cancer types,. Intratumoral host–microbiota studies have so far largely relied …

Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer

N Wang, JY Fang - Trends in Microbiology, 2023 - cell.com
Colorectal cancer (CRC), one of the most prevalent cancers, has complex etiology. The
dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC …

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

M Wang, B Rousseau, K Qiu, G Huang, Y Zhang… - Nature …, 2024 - nature.com
Increasing evidence implicates the tumor microbiota as a factor that can influence cancer
progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics …

Intratumoural microbiota: a new frontier in cancer development and therapy

Y Cao, H **a, X Tan, C Shi, Y Ma, D Meng… - … and Targeted Therapy, 2024 - nature.com
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several
physiological and pathological processes. Some studies discovered that tumour tissues …

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

G Hajishengallis, T Chavakis - Nature Reviews Immunology, 2021 - nature.com
Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Genetic and biological hallmarks of colorectal cancer

J Li, X Ma, D Chakravarti, S Shalapour… - Genes & …, 2021 - genesdev.cshlp.org
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …