Caenorhabditis elegans has emerged as a major model in biomedical and environmental
toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been …

The molecular basis of aging and of aging-associated diseases is being unraveled at an
increasing pace. An extended healthspan, and not merely an extension of lifespan, has …

The protein homeostasis (proteostasis) network encompasses a myriad of mechanisms that
maintain the integrity of the proteome by controlling various biological functions, including …

In C. elegans, removal of the germline triggers molecular events in the neighboring intestine,
which sends an anti-aging signal to the rest of the animal. In this study, we identified an …

Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a
central signaling pathway controlling immunity and inflammation. An alternative chromatin …

Background Extensive studies have been carried out on Caenorhabditis elegans as a model
organism to elucidate mechanisms of aging and the effects of perturbing known aging …

Dietary restriction (DR) refers to a reduction in food intake to induce undernutrition but not
malnutrition, which extends the lifespan of multiple species. Although there are invertebrate …

Scorpion venom could be a useful treatment for a variety of diseases, such as cancer,
epilepsy and analgesia. BmKTX is a polypeptide extracts from scorpion venom (PESV) …

From an epistemological point of view, nutritional physiology has been developed, like other
factual sciences such as physics, from a purely descriptive to a mechanismic-explanatory …

Numerous studies have demonstrated that many nutraceuticals have potential capacity to
mitigate the symptoms of aging and age-related disorders. We found that Royal Jelly …