Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Virus-like particles in vaccine development

A Roldão, MCM Mellado, LR Castilho… - Expert review of …, 2010 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Construction and characterization of virus-like particles: a review

A Zeltins - Molecular biotechnology, 2013 - Springer
Over the last three decades, virus-like particles (VLPs) have evolved to become a widely
accepted technology, especially in the field of vaccinology. In fact, some VLP-based …

[HTML][HTML] Genome sequence of the recombinant protein production host Pichia pastoris

K De Schutter, YC Lin, P Tiels, A Van Hecke… - Nature …, 2009 - nature.com
The methylotrophic yeast Pichia pastoris is widely used for the production of proteins and as
a model organism for studying peroxisomal biogenesis and methanol assimilation. P …

Rapid and sensitive anthrone–sulfuric acid assay in microplate format to quantify carbohydrate in biopharmaceutical products: Method development and validation

A Leyva, A Quintana, M Sánchez, EN Rodríguez… - Biologicals, 2008 - Elsevier
The need for an accurate, fast and reliable analysis of carbohydrate test is crucial for
numerous biological processes. In that sense, anthrone–sulfuric acid assay is one of the …

Yeast-based vaccines: New perspective in vaccine development and application

R Kumar, P Kumar - FEMS yeast Research, 2019 - academic.oup.com
In presently licensed vaccines, killed or attenuated organisms act as a source of
immunogens except for peptide-based vaccines. These conventional vaccines required a …

How far have we explored fungi to fight cancer?

CW How, YS Ong, SS Low, A Pandey, PL Show… - Seminars in cancer …, 2022 - Elsevier
The use of fungal cultures have been well documented in human history. Although its used
in healthcare, like penicillin and statins, have saved countless of lives, but there is still no …

Vaccine process technology

JO Josefsberg, B Buckland - Biotechnology and bioengineering, 2012 - Wiley Online Library
The evolution of vaccines (eg, live attenuated, recombinant) and vaccine production
methods (eg, in ovo, cell culture) are intimately tied to each other. As vaccine technology has …

A phase 3, randomised, double-blind, placebo-controlled clinical trial evaluation of the efficacy and safety of a SARS-CoV-2 recombinant spike RBD protein vaccine in …

F Hernández-Bernal, MC Ricardo-Cobas… - The Lancet Regional …, 2023 - thelancet.com
Background The pandemic of COVID-19 raised the urgent need for safe and efficacious
vaccines against SARS-CoV-2. We evaluated the efficacy and safety of a new SARS-CoV-2 …

[图书][B] Handbook of affinity chromatography

T Kline - 1993 - taylorfrancis.com
Outlining the fundamental principles by which all interactions occur, this reference focuses
on harnessing the biochemistry of bioorganic compounds in order to separate them …