Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …

In addition to long-distance molecular motor-mediated transport, cellular vesicles also need
to be moved at short distances with defined directions to meet functional needs in …

Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Neurotransmission is the electrical impulse-triggered propagation of signals between
neurons or between neurons and other cell types such as skeletal muscle cells. Recent …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Endocytosis mediates the uptake of extracellular proteins, micronutrients and
transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack …

Compensatory endocytosis keeps the membrane surface area of secretory cells constant
following exocytosis. At chemical synapses, clathrin-independent ultrafast endocytosis …

Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating
synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of …

Dynamin mediates fission of vesicles from the plasma membrane during endocytosis.
Typically, dynamin is recruited from the cytosol to endocytic sites, requiring seconds to tens …