The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with
translational arrests. The process is characterized by an endonucleolytic cleavage near the …

Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …

Nonsense mutations promote premature translational termination and cause anywhere from
5–70% of the individual cases of most inherited diseases. Studies on nonsense-mediated …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

Abstract mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3′
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …

An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Most eukaryotic mRNAs are subject to considerable post-transcriptional modification,
including cap**, splicing, and polyadenylation. The process of polyadenylation adds a …