Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Pancreatic ductal adenocarcinoma (PDA) has become one of the leading causes of cancer-
related deaths across the world. A lack of durable responses to standard-of-care …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression
in various tumors and is associated with a poor prognosis. FAK activation promotes tumor …

Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

Background: Metastasis is a major cause of HCC-related deaths with no effective
pharmacotherapies. Chronic inflammation promotes HCC dissemination, however, its …

Pancreatic cancer (PC) remains a leading cause of mortality worldwide due to the absence
of early detection methods and the low success rates of traditional therapeutic strategies …

Abstract Focal Adhesion Kinase (FAK) is a non-receptor protein tyrosine kinase that plays a
crucial role in various oncogenic processes related to cell adhesion, migration, proliferation …