The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Since the first recordings of single potassium channel activities in the plasma membrane of
guard cells more than 25 years ago, patch-clamp studies discovered a variety of ion …

In contrast to other members of the Eag family of voltage-gated, outwardly rectifying
potassium channels, the human eag-related gene (HERG) has now been shown to encode …

K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

Human epilepsies encompass a wide variety of clinical, behavioral and electrical
manifestations. Correspondingly, studies of this disease in nonhuman animals have brought …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM)
domain in each subunit and are ubiquitously expressed in both animals and plants as …

SKOR, a K+ channel identified in Arabidopsis, displays the typical hydrophobic core of the
Shaker channel superfamily, a cyclic nucleotide-binding domain, and an ankyrin domain …

In the central nervous system (CNS), the principal mediators of fast synaptic excitatory
neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate …