The central nervous system plays a critical role in the management of blood flow to the
tissues and its return to the heart and lungs. This is achieved by a complex interplay of …

There is a general agreement concerning the key role of the baroreceptor reflex in blood
pressure homeostasis. It is also well accepted that baroreceptor afferent messages are first …

CART-peptide (CARTp) has been shown to suppress food intake, particularly when injected
into the 4th ventricle of rats, and the presence of CART in nodose ganglia suggested a role …

Brainstem 5‐hydroxytryptamine (5‐HT, serotonin)‐containing neurones modulate
cardiovascular reflex responses but the differing roles of the many 5‐HT receptors have not …

Physical movement lasting any more than a few seconds (eg, exercise), requires
coordination of motor control with concomitant changes in the cardiovascular and respiratory …

Abstract Motivation Adverse drug reactions (ADRs) are a major issue in drug development
and clinical pharmacology. As most ADRs are caused by unintended activity at off-targets of …

Our first aim was to elucidate the mechanisms underlying the hypotensive response elicited
by 5‐HT2 receptor activation in the nucleus tractus solitarius (NTS). In pentobarbitone …

We previously showed that serotonin (5-HT2) receptor activation in the nucleus of the tractus
solitarius (NTS) produced hypotension, bradycardia, and facilitation of the baroreflex …

Background: Serotonin 2A receptors, the molecular target of psychedelics, are expressed by
neuronal and vascular cells, both of which might contribute to brain haemodynamic …

Serotonergic transmission is terminated by serotonin transporter (SERT)-mediated uptake
following activation of serotonin receptors, several subtypes of which are present in the …