Molecular mechanisms of ROS production and oxidative stress in diabetes
Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …
AMPK: an energy-sensing pathway with multiple inputs and outputs
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake
EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …
AMPK: a nutrient and energy sensor that maintains energy homeostasis
DG Hardie, FA Ross, SA Hawley - Nature reviews Molecular cell biology, 2012 - nature.com
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …
falling energy status, it promotes ATP production by increasing the activity or expression of …
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie - Genes & development, 2011 - genesdev.cshlp.org
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
CS Zhang, M Li, Y Wang, X Li, Y Zong, S Long… - Nature …, 2022 - nature.com
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …
correlated with the cellular availability of glucose. When glucose levels are low, the …
Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta… - Journal of medicinal …, 2017 - ACS Publications
Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …
AMPK in health and disease
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
AMPK and mTOR in cellular energy homeostasis and drug targets
The mammalian target of rapamycin (mTOR) is a central controller of cell growth and
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …
AMPK: a target for drugs and natural products with effects on both diabetes and cancer
DG Hardie - Diabetes, 2013 - Am Diabetes Assoc
The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy
that appears to have arisen at an early stage during eukaryotic evolution. In 2001 it was …
that appears to have arisen at an early stage during eukaryotic evolution. In 2001 it was …