The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that
colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Kisspeptin stimulates reproduction, and kisspeptin cells in the arcuate nucleus (ARC)
express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether …

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …

Kisspeptins are the product of the Kiss1 gene and potently stimulate GnRH secretion. In
sheep, Kiss1 mRNA-expressing cells are found in the arcuate nucleus (ARC) and dorsal …

Reproductive activity in sheep is seasonal, being activated by short-day photoperiods and
inhibited by long days. During the nonbreeding season, GnRH secretion is reduced by both …