Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Cells migrate in multiple different ways depending on their environment, which includes the
extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …

There is growing appreciation of the importance of the mechanical properties of the tumor
microenvironment on disease progression. However, the role of extracellular matrix (ECM) …

Members of the protein superfamily of small guanosine triphosphatases, also known as
small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect …

Bundled with various kinds of adhesion molecules and anchored to the basement
membrane, the epithelium has historically been considered as an immotile tissue and, to …

In this article, we provide detailed protocols on using optogenetic dimerizers to acutely
perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho …

Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is
a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of …

Receptor tyrosine kinase-mediated growth factor signaling is essential for proper formation
and development of the neural crest. The many ligands and receptors implicated in these …