Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …

The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in …

Inherited genetic variation has a critical but as yet largely uncharacterized role in human
disease. Here we report a public database of common variation in the human genome: more …

The nature and scale of recombination rate variation are largely unknown for most species.
In humans, pedigree analysis has documented variation at the chromosomal level, and …

Our basic question is: Given a collection of DNA sequences, what underlying forces are
responsible for the observed patterns of variability? To approach this question we introduce …

There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-map** studies and …

Individual differences in DNA sequence are the genetic basis of human variability. We have
characterized whole-genome patterns of common human DNA variation by genoty** …

Scanners for conventional microarrays typically have imaging spot sizes in the range of 3–5
microns, insufficient to resolve the~ 5-micron-spaced features on the randomly assembled …

Ninety per cent of the human population has been right-handed since the Paleolithic, yet the
brain signature and genetic basis of handedness remain poorly characterized. Here, we …