The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Accumulating evidence indicates that breakdown of the+ protective mucosal barrier of the
gut plays a role in colorectal cancer (CRC) development. Inflammation and oxidative stress …

Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis
and integrity through the control of paracellular permeability and cell polarity. Recent …

Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal
barrier, otherwise known as “leaky gut,” is alleged to promote mucosal inflammation by …

Colorectal cancer (CRC) is a heterogeneous disease that commonly affects individuals
aged more than 50 years old globally. Regular colorectal screening, which is recommended …

Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …

TJs are large intercellular adhesion complexes that maintain cell polarity in normal epithelia
and endothelia. During the metastatic process, TJs must be 'loosened'or dismantled in …

Claudins are a multigene transmembrane protein family comprising at least 27 members. In
gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of …

Inflammatory bowel disease (IBD) involves chronic inflammation, loss of epithelial integrity,
and gastrointestinal microbiota dysbiosis, resulting in the development of a colon cancer …