Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

Extensive human epidemiologic and animal model data indicate that during critical periods
of prenatal and postnatal mammalian development, nutrition and other environmental stimuli …

Metabolites affect cell growth in two different ways. First, they serve as building blocks for
biomass accumulation. Second, metabolites regulate the activity of growth-relevant …