Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009–2020)

M Kurakula - International Journal of Biological Macromolecules, 2020 - Elsevier
Improved accuracy is one of the vital innovations in designing biopolymer-based products
that are gaining momentum in diverse biomedicine arenas. The innovative devices were …

Recent trends in design and evaluation of chitosan-based colon targeted drug delivery systems: Update 2020

M Kurakula, S Gorityala, K Moharir - Journal of Drug Delivery Science and …, 2021 - Elsevier
Colon-targeted drug delivery systems is an active area of research that is designed to
selectively release the drug in the colonic environment to enhance the oral delivery of active …

Electrospraying: A facile technology unfolding the chitosan based drug delivery and biomedical applications

M Kurakula, NR Naveen - European Polymer Journal, 2021 - Elsevier
Chitosan (CS) a promising biopolymer has been explored for wide biomedical applications
using different technologies. Electrospraying is one of the advancing liquid atomization …

Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Y **a, Y **, D Cui, X Wu, C Song, W **… - Frontiers in …, 2022 - frontiersin.org
Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell
death, which can be triggered by caspase-3 activation upon stimulation. Silenced GSDME …

Design and development of neomycin sulfate gel loaded with solid lipid nanoparticles for buccal mucosal wound healing

KM Hosny, NR Naveen, M Kurakula, AM Sindi… - Gels, 2022 - mdpi.com
Drug administration to the wound site is a potential method for wound healing. The drug
retention duration should be extended, and drug permeability through the buccal mucosal …

Cross-linked quaternized chitosan nanoparticles for effective delivery and controllable release of O. europaea phenolic extract targeting cancer therapy

BH Asghar, RKA Hassan, LAA Barakat… - Journal of Drug Delivery …, 2023 - Elsevier
Although current therapies for cancer patients have saved many lives, finding more effective
remedies is still a challenge. To that end, we have begun to explore the potential of cross …

RETRACTED: The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells

ZA Awan, UA Fahmy, SM Badr-Eldin, TS Ibrahim… - Pharmaceutics, 2020 - mdpi.com
Statins, including simvastatin (SMV), are commonly used for the control of hyperlipidaemia
and have also proven therapeutic and preventative effects in cardiovascular diseases …

Advances in functionalized hybrid biopolymer augmented lipid-based systems: A spotlight on their role in design of gastro retentive delivery systems

P Basim, S Gorityala… - Archives of …, 2021 - scientificarchives.com
Biopolymers are the polymers extracted from living organisms either from renewable plant or
animal sources are gaining importance due to their better biodegradability, biocompatibility …

RETRACTED: Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity

NA Alhakamy, OAA Ahmed, M Kurakula, G Caruso… - Pharmaceutics, 2020 - mdpi.com
This study aimed at improving the targeting and cytotoxic effect of ellagic acid (EA) on colon
cancer cells. EA was encapsulated in chitosan (CHIT) polymers then coated by eudragit …

Colon targeted releases and uptakes of paclitaxel loaded in modified porous starch

B Zhao, Z Gu, Z Li, L Cheng, C Li, Y Hong - Carbohydrate Polymers, 2023 - Elsevier
Hyaluronic acid can modify porous starch through cross-linking and hydrogen bonding,
effectively achieving a paclitaxel entrapment efficiency of∼ 92% and drug loading of∼ 23 …