[HTML][HTML] Influenza A: understanding the viral life cycle

T Samji - The Yale journal of biology and medicine, 2009 - ncbi.nlm.nih.gov
Influenza A virus belongs to the family of Orthomyxoviridae. It is an enveloped virus with a
negative sense RNA segmented genome that encodes for 11 viral genes. This virus has …

Influenza virus morphogenesis and budding

DP Nayak, RA Balogun, H Yamada, ZH Zhou… - Virus research, 2009 - Elsevier
Influenza viruses are enveloped, negative stranded, segmented RNA viruses belonging to
Orthomyxoviridae family. Each virion consists of three major sub-viral components, namely …

Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis

Y Chou, NS Heaton, Q Gao, P Palese, R Singer… - PLoS …, 2013 - journals.plos.org
The Influenza A virus genome consists of eight negative sense, single-stranded RNA
segments. Although it has been established that most virus particles contain a single copy of …

Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches

D Mayer, K Molawi, L Martínez-Sobrido… - Journal of proteome …, 2007 - ACS Publications
Cellular factors that associate with the influenza A viral ribonucleoprotein (vRNP) are
presumed to play important roles in the viral life cycle. To date, interaction screens using …

Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virions

SL Noton, E Medcalf, D Fisher… - Journal of General …, 2007 - microbiologyresearch.org
The matrix (M1) protein of influenza A virus is a multifunctional protein that plays essential
structural and functional roles in the virus life cycle. It drives virus budding and is the major …

Host-and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins

E Bortz, L Westera, J Maamary, J Steel, RA Albrecht… - MBio, 2011 - Am Soc Microbiol
Highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype have recently
emerged from avian zoonotic reservoirs to cause fatal human disease. Adaptation of HPAI …

Transport of the influenza virus genome from nucleus to nucleus

EC Hutchinson, E Fodor - Viruses, 2013 - mdpi.com
The segmented genome of an influenza virus is encapsidated into ribonucleoprotein
complexes (RNPs). Unusually among RNA viruses, influenza viruses replicate in the …

Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit

F Tarendeau, T Crepin, D Guilligay… - PLoS …, 2008 - journals.plos.org
Understanding how avian influenza viruses adapt to human hosts is critical for the
monitoring and prevention of future pandemics. Host specificity is determined by multiple …

Use of aptamers as diagnostics tools and antiviral agents for human viruses

VM González, ME Martín, G Fernández… - Pharmaceuticals, 2016 - mdpi.com
Appropriate diagnosis is the key factor for treatment of viral diseases. Time is the most
important factor in rapidly develo** and epidemiologically dangerous diseases, such as …

Functional association between viral and cellular transcription during influenza virus infection

OG Engelhardt, E Fodor - Reviews in medical virology, 2006 - Wiley Online Library
Influenza viruses replicate and transcribe their segmented negative‐sense single‐stranded
RNA genome in the nucleus of the infected host cell. All RNA synthesising activities …