Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells

EY Makhani, A Zhang, JB Haun - Nano Convergence, 2021 - Springer
Nanoparticles have drawn intense interest as delivery agents for diagnosing and treating
various cancers. Much of the early success was driven by passive targeting mechanisms …

Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery

DM Eckmann, RP Bradley, SK Kandy, K Patil… - Current opinion in …, 2020 - Elsevier
Highlights•Computational methods for modeling hydrodynamic factors in nanoparticle
membrane interactions in targeted drug delivery.•Computational frameworks for predicting …

Nondestructively Assemble Cell Membrane-Coated Nanoparticles by Host–Guest Interactions for Efficient Capture of Bioactive Compounds

Q Hu, Z Wang, J Li, W Cao, P Li, X **e… - Analytical …, 2024 - ACS Publications
Cell membrane-coated nanoparticles (CNPs) have emerged as an attractive nanomedical
tool. The basic premise is that the surface properties of natural cells can be integrated with …

The Quantity of Ligand-Receptor Interactions between Nanoparticles and Target Cells

K Schorr, S Beck, O Zimmer, FJ Baumann… - Nanoscale …, 2025 - pubs.rsc.org
Achieving high target cell avidity in combination with cell selectivity are fundamental, but
largely unachieved goals in the development of biomedical nanoparticle systems, which are …

Adhesion dynamics of functionalized nanocarriers to endothelial cells: a dissipative particle dynamics study

S Akbarishandiz, S Khani, J Maia - Soft Matter, 2023 - pubs.rsc.org
Targeted drug delivery to endothelial cells utilizing functionalized nanocarriers (NCs) is an
essential procedure in therapeutic and diagnosis therapies. Using dissipative particle …

Nanoparticles in bodily tissues: predicting their equilibrium distributions

TM Nolte, B Lu, AJ Hendriks - Environmental Science: Nano, 2023 - pubs.rsc.org
Nanoparticles (NPs) interact within organisms via various biochemical interactions which
can bring benefits to society. Classically, fate/distribution of substances is assessed via …

Systemically applicable glutamine-functionalized polymer exerting multivalent interaction with tumors overexpressing ASCT2

Y Honda, T Nomoto, H Takemoto, M Matsui… - ACS Applied Bio …, 2021 - ACS Publications
Transporter ASCT2, which predominantly imports glutamine (Gln), is overexpressed in a
variety of cancer cells, and targeting ASCT2 is expected to be a promising approach for …

Biophysical considerations in the rational design and cellular targeting of flexible polymeric nanoparticles

S Farokhirad, SK Kandy, A Tsourkas… - Advanced materials …, 2021 - Wiley Online Library
How nanoparticle (NP) mechanical properties impact multivalent ligand–receptor‐mediated
binding to cell surfaces, the avidity, propensity for internalization, and effects due to …

Computational Study of Near Wall Dynamics and Adhesion of Functionalized Nanocarriers to Endothelial Cells

S Akbarishandiz - 2024 - search.proquest.com
This dissertation delves into a comprehensive computational investigation of the intricate
behavior of macromolecules at both the liquid/liquid and solid/liquid interfaces. By …

Entropic Pressure on a Biological Vesicle with Surface Tension

R Hassan, M Cai, ATN Vo, S Farokhirad, X Yan… - Available at SSRN … - papers.ssrn.com
Entropic forces play a critical role in the dynamics and stability of soft matter systems, par-
ticularly in biological membranes and vesicles. The origin of these forces lies in the …