Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Einkorn (Triticum monococcum) was the first domesticated wheat species, and was central
to the birth of agriculture and the Neolithic Revolution in the Fertile Crescent around 10,000 …

The centromere represents a single region in most eukaryotic chromosomes. However,
several plant and animal lineages assemble holocentromeres along the entire chromosome …

The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to
be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has …

During development, progenitors simultaneously activate one lineage while silencing
another, a feature highly regulated in adult stem cells but derailed in cancers. Equipped to …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin
modifications and three-dimensional genome architecture; however, causal links have not …

Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …