Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective

Y Yang, Z Lin, Q Lin, W Bei, J Guo - Cell death & disease, 2022 - nature.com
Abstract Trefoil factor 3 (TFF3) is the last small-molecule peptide found in the trefoil factor
family, which is mainly secreted by intestinal goblet cells and exerts mucosal repair effect in …

Neo-vascularization-based therapeutic perspectives in advanced ovarian cancer

V Bhardwaj, X Zhang, V Pandey, M Garg - Biochimica et Biophysica Acta …, 2023 - Elsevier
The process of angiogenesis is well described for its potential role in the development of
normal ovaries, and physiological functions as well as in the initiation, progression, and …

Enhanced isolation and release of circulating tumor cells using nanoparticle binding and ligand exchange in a microfluidic chip

MH Park, E Reátegui, W Li, SN Tessier… - Journal of the …, 2017 - ACS Publications
The detection of rare circulating tumor cells (CTCs) in the blood of cancer patients has the
potential to be a powerful and noninvasive method for examining metastasis, evaluating …

Delivery of miR-200c-3p using tumor-targeted mesoporous silica nanoparticles for breast cancer therapy

I Garrido-Cano, A Adam-Artigues… - … Applied Materials & …, 2023 - ACS Publications
Despite advances in breast cancer treatment, it remains the leading cause of cancer-related
death in women worldwide. In this context, microRNAs have emerged as potential …

Subtype-GAN: a deep learning approach for integrative cancer subty** of multi-omics data

H Yang, R Chen, D Li, Z Wang - Bioinformatics, 2021 - academic.oup.com
Motivation The discovery of cancer subty** can help explore cancer pathogenesis,
determine clinical actionability in treatment, and improve patients' survival rates. However …

TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma

S Zhang, YQ Tan, X Zhang, B Basappa, T Zhu… - Oncogene, 2024 - nature.com
Intrinsic and acquired resistance represent major obstacles to optimize outcomes in
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeted therapy in …

TFF3 and TFF1 expression levels are elevated in colorectal cancer and promote the malignant behavior of colon cancer by activating the EMT process

A Yusufu, P Shayimu, R Tuerdi… - International …, 2019 - spandidos-publications.com
Reports on the roles of the secreted trefoil factor (TFF) 1 and 3 in colorectal cancer (CRC)
and their underlying mechanisms of action in tumorigenesis are not common and are …

Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression

F Cheng, X Wang, YS Chiou, C He, H Guo… - Cell death & …, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with
a dismal prognosis that has changed little over the past few decades. Further understanding …

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation

V Pandey, B Wang, CD Mohan… - Proceedings of the …, 2018 - National Acad Sciences
Human BCL-2–associated death promoter (hBAD) is an apoptosis-regulatory protein
mediating survival signals to carcinoma cells upon phosphorylation of Ser99, among other …

[HTML][HTML] TFF3 contributes to epithelial-mesenchymal transition (EMT) in papillary thyroid carcinoma cells via the MAPK/ERK signaling pathway

X Lin, H Zhang, J Dai, W Zhang, J Zhang, G Xue… - Journal of …, 2018 - ncbi.nlm.nih.gov
Trefoil factor 3 (TFF3) was found to be overexpressed in many types of tumours. Evidence
has shown that TFF3 plays an important role in tumour proliferation, migration and invasion …