MRI to differentiate multiple sclerosis, neuromyelitis optica, and myelin oligodendrocyte glycoprotein antibody disease

E Carnero Contentti, DT Okuda, JI Rojas… - Journal of …, 2023 - Wiley Online Library
Differentiating multiple sclerosis (MS) from other relapsing inflammatory autoimmune
diseases of the central nervous system such as neuromyelitis optica spectrum disorder …

[HTML][HTML] Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues

F La Rosa, M Wynen, O Al-Louzi, ES Beck… - NeuroImage: Clinical, 2022 - Elsevier
The current diagnostic criteria for multiple sclerosis (MS) lack specificity, and this may lead to
misdiagnosis, which remains an issue in present-day clinical practice. In addition …

Diagnostic performance of cortical lesions and the central vein sign in multiple sclerosis

A Cagol, R Cortese, M Barakovic, S Schaedelin… - JAMA …, 2024 - jamanetwork.com
Importance Multiple sclerosis (MS) misdiagnosis remains an important issue in clinical
practice. Objective To quantify the performance of cortical lesions (CLs) and central vein …

Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions

A de Boer, AMR van den Bosch, NJ Mekkes… - Acta …, 2024 - Springer
Multiple sclerosis (MS) is a heterogeneous neurological disorder with regards to clinical
presentation and pathophysiology. Here, we investigated the heterogeneity of MS by …

A novel imaging marker of cortical “cellularity” in multiple sclerosis patients

M Barakovic, M Weigel, A Cagol, S Schaedelin… - Scientific reports, 2024 - nature.com
Pathological data showed focal inflammation and regions of diffuse neuronal loss in the
cortex of people with multiple sclerosis (MS). In this work, we applied a novel model (“soma …

Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis

A Lazzarotto, M Hamzaoui, M Tonietto, AL Dubessy… - Brain, 2024 - academic.oup.com
Cortical myelin loss and repair in multiple sclerosis (MS) have been explored in
neuropathological studies, but the impact of these processes on neurodegeneration and the …

[HTML][HTML] From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions

H Kolb, O Al-Louzi, ES Beck, P Sati, M Absinta… - NeuroImage: Clinical, 2022 - Elsevier
Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS).
Histopathological studies have helped define the main underlying pathological processes …

Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis

EA Krijnen, E Salim Karam, AW Russo… - Annals of Clinical …, 2024 - Wiley Online Library
Objective To evaluate the intrinsic and extrinsic microstructural factors contributing to
atrophy within individual thalamic subregions in multiple sclerosis using in vivo high …

Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis

O Mirmosayyeb, M Yazdan Panah, Y Mokary… - PLoS …, 2024 - journals.plos.org
Background Multiple sclerosis (MS) is a central nervous system disorder marked by
progressive neurological impairments. Magnetic resonance imaging (MRI) parameters are …

Highly sensitive 3-Tesla real inversion recovery MRI detects leptomeningeal contrast enhancement in chronic active multiple sclerosis

SV Okar, H Dieckhaus, ES Beck, MI Gaitán… - Investigative …, 2024 - journals.lww.com
Background Leptomeningeal contrast enhancement (LME) on T2-weighted Fluid-Attenuated
Inversion Recovery (T2-FLAIR) MRI is a reported marker of leptomeningeal inflammation …