VDAC channels exist in the mitochondrial outer membrane of all eukaryotic organisms. Of
the different isoforms present in one organism, it seems that one of these is the canonical …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

Transport of ions through pores in membranes is a process of fundamental importance to
cell biology. In living organisms, such transport is facilitated by ion channels that utilize the …

Cancer metabolism is emerging as a chemotherapeutic target. Enhanced glycolysis and
suppression of mitochondrial metabolism characterize the Warburg phenotype in cancer …

Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate
(ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the …

We review the current state of membrane protein structure determination using solid-state
nuclear magnetic resonance (NMR) spectroscopy. Multidimensional magic-angle-spinning …

Steroid hormones are essential for carbohydrate metabolism, stress management, and
reproduction and are synthesized from cholesterol in mitochondria of adrenal glands and …

The amount of Ca2+ taken up in the mitochondrial matrix is a crucial determinant of cell fate;
it plays a decisive role in the choice of the cell between life and death. The Ca2+ ions mainly …

Mitochondria play an essential role in cellular metabolism and generate energy in cells. To
support these functions, several proteins are encoded in the mitochondrial DNA (mtDNA) …