Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Mobile genetic elements are key to the evolution of bacteria and traits that affect host and
ecosystem health. Here, we use a framework of a hierarchical and modular system that …

P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and
new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains …

Plasmids play an important role in bacterial genome evolution by transferring genes
between lineages. Fitness costs associated with plasmid carriage are expected to be a …

Disinfectants are widely acknowledged for removing microorganisms from the surface of the
objects and transmission media. However, the emergence of disinfectant resistance has …

Naturally occurring plasmids come in different sizes. The smallest are less than a kilobase of
DNA, while the largest can be over three orders of magnitude larger. Historically, research …

This review will consider the gut as a reservoir for antimicrobial resistance, colonization
resistance, and how disruption of the microbiome can lead to colonization by pathogenic …

CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …

The use and misuse of antibiotics have made antibiotic-resistant bacteria widespread
nowadays, constituting one of the most relevant challenges for human health at present …

Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …