Guanine's array of hydrogen bond donors and acceptors lead it to take part in structures as
diverse as B-DNA, Z-DNA, hairpins, cruciforms, triplexes, and G-quadruplexes; these …

Olignucleotide-based drugs show promise as a novel form of chemotherapy. Among the
hurdles that have to be overcome on the way of applicable nucleic acid therapeutics …

Nucleic acid-based aptamers can be selected from combinatorial libraries of synthetic
oligonucleotides to bind, with affinity and specificity similar to antibodies, a wide range of …

Though a variety of different non-canonical nucleic acids conformations have been
recognized, G-quadruplex structures are probably the structural motifs most commonly found …

Electrospray mass spectrometry was used to investigate the mechanism of tetramolecular G-
quadruplex formation by the DNA oligonucleotide dTG 5 T, in ammonium acetate. The …

From the early days of research on RNA biology and biochemistry, there was an interest to
utilize this knowledge and RNA itself for therapeutic applications. Today, we have a series of …

Conjugation of oligonucleotides (ONs) to a variety of reporter groups has been the subject of
intensive research during the last decade. Conjugation is indeed of great interest because it …

As part of a program of preparing metal complexes which exhibit unique affinities towards
different DNA structures, we have synthesised the novel Schiff base complex N, N′-bis-4 …

This account discusses construction strategies for various functional biomaterials based on
the designed self-assembly of biomolecules. Novel glycoclusters with regular intervals were …

Two G-quadruplex forming sequences, 5′-TGGGAG and the 17-mer sequence T30177,
which exhibit anti-HIV-1 activity on cell lines, were modified using either locked nucleic acids …