Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

DJ Hausenloy, DM Yellon - The Journal of clinical …, 2013 - Am Soc Clin Investig
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force on the management of ST …

Authors/Task Force Members, PG Steg… - European heart …, 2012 - academic.oup.com
The task of develo** ESC Guidelines covers not only the integration of the most recent
research, but also the creation of educational tools and implementation programmes for the …

Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

[HTML][HTML] Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised …

DJ Hausenloy, RK Kharbanda, UK Møller, M Ramlall… - The Lancet, 2019 - thelancet.com
Background Remote ischaemic conditioning with transient ischaemia and reperfusion
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …

Ischaemic conditioning and reperfusion injury

DJ Hausenloy, DM Yellon - Nature Reviews Cardiology, 2016 - nature.com
The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …

P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - Elsevier
Abstract Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

Short-and long-term cause of death in patients treated with primary PCI for STEMI

F Pedersen, V Butrymovich, H Kelbæk… - Journal of the American …, 2014 - jacc.org
Background: Short-term mortality has been studied thoroughly in patients undergoing
primary percutaneous coronary intervention (PCI), whereas long-term cause of death in …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …