Linking EMT programmes to normal and neoplastic epithelial stem cells
AW Lambert, RA Weinberg - Nature Reviews Cancer, 2021 - nature.com
Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …
and repair of diverse tissues through their ability to self-renew and spawn more specialized …
Rho GTPase signaling in cancer progression and dissemination
E Crosas-Molist, R Samain… - Physiological …, 2022 - journals.physiology.org
Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …
Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis
Small cell lung cancer is initially highly responsive to cisplatin and etoposide but in almost
every case becomes rapidly chemoresistant, leading to death within 1 year. We modeled …
every case becomes rapidly chemoresistant, leading to death within 1 year. We modeled …
The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis
YBY Sun, X Qu, G Caruana, J Li - Differentiation, 2016 - Elsevier
Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …
Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
Revisiting epithelial‐mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness
TT Liao, MH Yang - Molecular oncology, 2017 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is an important process in embryonic
development, fibrosis, and cancer metastasis. During cancer progression, the activation of …
development, fibrosis, and cancer metastasis. During cancer progression, the activation of …
Multilayer control of the EMT master regulators
Metastasis is the leading cause of cancer-associated death in most tumor types. Metastatic
dissemination of cancer cells from the primary tumor is believed to be initiated by the …
dissemination of cancer cells from the primary tumor is believed to be initiated by the …
A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer
Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
Research progress of TXNIP as a tumor suppressor gene participating in the metabolic reprogramming and oxidative stress of cancer cells in various cancers
Y Chen, J Ning, W Cao, S Wang, T Du, J Jiang… - Frontiers in …, 2020 - frontiersin.org
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate
oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of …
oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of …
[HTML][HTML] Snail-overexpressing cancer cells promote M2-like polarization of tumor-associated macrophages by delivering MiR-21-abundant exosomes
Epithelial-mesenchymal transition (EMT) is a major event during cancer progression and
metastasis; however, the definitive role of EMT in remodeling tumor microenvironments …
metastasis; however, the definitive role of EMT in remodeling tumor microenvironments …