The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

The cell orchestrates the dance of chromosome segregation with remarkable speed and
fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) …

Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …

Liquid–liquid phase separation, occurs not only in bulk liquid, but also on surfaces. In
physiology, the nature and function of condensates on cellular structures remain …

Dividing cells reorganize their microtubule cytoskeleton into a bipolar spindle, which moves
one set of sister chromatids to each nascent daughter cell. Early spindle assembly models …

Microtubules are nucleated from specific locations at precise times in the cell cycle.
However, the factors that constitute these microtubule nucleation pathways and their mode …

Successive cell divisions during embryonic cleavage create increasingly smaller cells, so
intracellular structures must adapt accordingly. Mitotic spindle size correlates with cell size …

The purpose of this review is to explore self-organizing mechanisms that pattern
microtubules (MTs) and spatially organize animal cell cytoplasm, inspired by recent …

The microtubule (MT) cytoskeleton provides the architecture that governs intracellular
organization and the regulated motion of macromolecules through the crowded cytoplasm …