Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

The sigma-1 (σ1) receptor, an enigmatic protein originally classified as an opioid receptor
subtype, is now understood to possess unique structural and functional features of its own …

Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …

Recent studies have brought to light the necessity to discern sex-specific differences in
various pain states and different cell-types that mediate these differences. These studies …

Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the
neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by …

Immune and glial cells play a pivotal role in chronic pain. Therefore, it is possible that the
pharmacological modulation of neurotransmission from an exclusively neuronal perspective …

Paclitaxel (PTX), a drug widely used in lung cancer, has serious limitations including the
development of peripheral neurotoxicity, which may lead to treatment discontinuation and …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …

Dexmedetomidine is known to alleviate cerebral ischemia-reperfusion injury (CIRI). We
established a rat model of CIRI, which exhibited higher neurological deficit scores and a …

The analgesic effects of sigma-1 antagonists are undisputed, but the effects of sigma-1
agonists on pain are not well studied. Here, we used a mouse model to show that the …