Troponin is a heterotrimeric Ca2+-binding protein that has a well-established role in
regulating striated muscle contraction. However, mounting evidence points to novel cellular …

Could enzymatic activities and their cooperative functions act as cellular temperature-
sensing systems? This review introduces recent opto-thermal technologies for microscopic …

Contraction of striated muscles is initiated by an increase in cytosolic Ca2+ concentration,
which is regulated by tropomyosin and troponin acting on actin filaments at the sarcomere …

Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …

Acto-myosin cross-bridge kinetics are important for beat-to-beat regulation of cardiac
contractility; however, physiological and pathophysiological mechanisms for regulation of …

In the present study, we investigated the effects of infra-red laser irradiation on sarcomere
dynamics in living neonatal cardiomyocytes of the rat. A rapid increase in temperature to>∼ …

Investigations of cardiomyopathy mutations in Ca 2+ regulatory proteins troponin and
tropomyosin provide crucial information about cardiac disease mechanisms, and also …

Tropomyosin and troponin have well known Ca 2+-regulatory functions in the striated
muscle sarcomere. In this review, we summarize experimental evidence that tropomyosin …

The past decade has witnessed several significant efforts made towards implementing the
biomolecular functions of motor proteins for nanotechnological applications. However …

During the excitation–contraction coupling of the heart, sarcomeres are activated via thin
filament structural changes (ie, from the “off” state to the “on” state) in response to a release …