Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Employees who drink heavily or who abuse or are dependent on alcohol can undermine a
workforce's overall health and productivity. To better understand the reasons behind …

The central nervous system (CNS) effects of acute alcohol administration have been
frequently assessed. Such studies often use a wide range of methods to study each of these …

This study developed and tested a moderated-mediation model of work stress and alcohol
use, based on the biphasic (stimulant and sedative) effects of alcohol and the self …

The zebrafish is a powerful whole animal model which is complementary to in vitro and
mammalian models. It has been shown to be applicable to the high-throughput behavioral …

High-throughput behavioral studies using larval zebrafish often assess locomotor activity to
determine the effects of experimental perturbations. However, the results reported by …

Several theories posit problematic alcohol use develops through mechanisms of positive
and negative reinforcement. However, the literature on these mechanisms remains …

Background How the biophysics of electrical conductivity measures relate to brain activity is
poorly understood. The sedative, ethanol, reduces metabolic activity but its impact on brain …

Driving under the influence of alcohol is an ongoing cause of road traffic accidents. The
biphasic nature of alcohol effects on subjective experience appears to contribute to the …

A current survey and synthesis of the most important findings in our understanding of the
neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series …