Molecular regulation of antibiotic biosynthesis in Streptomyces
G Liu, KF Chater, G Chandra, G Niu… - … and molecular biology …, 2013 - Am Soc Microbiol
Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …
The TetR family of regulators
L Cuthbertson, JR Nodwell - Microbiology and Molecular Biology …, 2013 - Am Soc Microbiol
The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …
Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era
HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …
[HTML][HTML] Recent advances in understanding Streptomyces
KF Chater - F1000Research, 2016 - ncbi.nlm.nih.gov
Abstract About 2,500 papers dated 2014–2016 were recovered by searching the PubMed
database for Streptomyces, which are the richest known source of antibiotics. This review …
database for Streptomyces, which are the richest known source of antibiotics. This review …
[HTML][HTML] Activation of microbial secondary metabolic pathways: Avenues and challenges
B Baral, A Akhgari, M Metsä-Ketelä - Synthetic and Systems Biotechnology, 2018 - Elsevier
Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …
drug discovery. Next generation sequencing has revealed an unprecedented genomic …
Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis
Covering: 1997 to 2010 The angucycline group is the largest group of type II PKS-
engineered natural products, rich in biological activities and chemical scaffolds. This …
engineered natural products, rich in biological activities and chemical scaffolds. This …
An engineered strong promoter for streptomycetes
Well-characterized promoters are essential tools for metabolic engineering and synthetic
biology. In Streptomyces coelicolor, the native kasO p is a temporally expressed promoter …
biology. In Streptomyces coelicolor, the native kasO p is a temporally expressed promoter …
The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining
H **a, X Li, Z Li, X Zhan, X Mao, Y Li - Frontiers in microbiology, 2020 - frontiersin.org
Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …
and other bio-active natural products, which have been widely used in pharmaceutical and …
Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.
G Niu, KF Chater, Y Tian, J Zhang… - FEMS Microbiology …, 2016 - academic.oup.com
Streptomyces bacteria are the major source of antibiotics and other secondary metabolites.
Various environmental and physiological conditions affect the onset and level of production …
Various environmental and physiological conditions affect the onset and level of production …
Activation of silent biosynthetic gene clusters using transcription factor decoys
Here we report a transcription factor decoy strategy for targeted activation of eight large
silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging …
silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging …