Cell migration is a highly integrated multistep process that orchestrates embryonic
morphogenesis; contributes to tissue repair and regeneration; and drives disease …

This review summarizes what is known about the biochemical and biophysical mechanisms
that initiate the assembly of actin filaments in cells. Assembly and disassembly of these …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …

The SH3 domain is perhaps the best-characterized member of the growing family of protein-
interaction modules. By binding with moderate affinity and selectivity to proline-rich ligands …

Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed
by invasive cancer cells. We have studied the molecular mechanisms of invadopodium …

▪ Abstract Phosphoinositides [PPIs, which collectively refer to phosphorylated derivatives of
phosphatidylinositol (PI)] have a pivotal role as precursors to important second messengers …

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

▪ Abstract Eukaryotic cells use actin polymerization to change shape, move, and internalize
extracellular materials by phagocytosis and endocytosis, and to form contractile structures …

▪ Abstract Actin filament assembly and turnover drive many forms of cellular motility,
particularly extension of the leading edge of locomoting cells and rocketing of pathogenic …

Reorganization of cortical actin filaments plays critical roles in cell movement and pattern
formation. Recently, the WASP and WAVE family proteins WASP and N-WASP, and WAVE1 …