Many factors have contributed to rendering frailty an emerging, relevant, and very popular
concept. First, many pandemics that have affected humanity in history, including COVID-19 …

Frailty and delirium are two common geriatric syndromes sharing several clinical
characteristics, risk factors, and negative outcomes. Understanding their interdependency is …

Importance An accessible marker of both biological age and dementia risk is crucial to
advancing dementia prevention and treatment strategies. Although frailty is a candidate for …

Background Dementia and frailty are common age-related syndromes often linked to chronic
inflammation. Identifying the biological factors and pathways that contribute to chronic …

Background: Altered cell homeostasis, seen in cognitive decline and frailty, leads to cell
death and turnover, releasing circulating cell-free DNA (ccf-DNA). Objective: The goal of this …

Introduction Frailty is a geriatric syndrome that is highly susceptible to adverse health
outcomes and is a major burden that exacerbates society's medical care. By investigating …

The National Institute on Aging and the Alzheimer's Association (NIA-AA) workgroups
presented the revised guidelines for clinical diagnosis of Alzheimer's disease at AAIC 2023 …

Background This study aimed to assess the associations of orthostatic hypotension (OH), in
the presence or absence of frailty, with dementia and mortality in older adults. Methods We …

Background Cognitive impairment and physical frailty are common among older adults and
associated with a higher likelihood of adverse health outcomes. These two conditions …

The 5xFAD mouse model shows age-related weight loss as well as cognitive and motor
deficits. Metabolic dysregulation, especially impaired insulin signaling, is also present in AD …