The role of sex in the genomics of human complex traits
Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …
differences, including differences in prevalence, age of onset, severity or disease …
Genome-wide sex and gender differences in cancer
Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …
are among the least studied factors affecting cancer susceptibility, progression, survival, and …
Gene regulatory network analysis identifies sex-linked differences in colon cancer drug metabolism
Understanding sex differences in colon cancer is essential to advance disease prevention,
diagnosis, and treatment. Males have a higher risk of develo** colon cancer and a lower …
diagnosis, and treatment. Males have a higher risk of develo** colon cancer and a lower …
Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology
Increased knowledge about sex differences is important for development of individualized
treatments against many diseases as well as understanding behavioral and pathological …
treatments against many diseases as well as understanding behavioral and pathological …
Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish
We have previously demonstrated the pro-tumoral role of neutrophils using a kras-induced
zebrafish hepatocarcinogenesis model. To further illustrate the molecular basis of the pro …
zebrafish hepatocarcinogenesis model. To further illustrate the molecular basis of the pro …
Cartilage debris and osteoarthritis risk factors influence gene expression in the synovium in end stage osteoarthritis
Background Gene expression in healthy synovium remains poorly characterised. Thus,
synovial functional activity changes associated with osteoarthritis (OA) are difficult to define …
synovial functional activity changes associated with osteoarthritis (OA) are difficult to define …
Sex, immunity, and cancer
The composition of the tumor microenvironment is the complex result of the interaction
between tumoral and host factors. Since there are several differences in the regulation of …
between tumoral and host factors. Since there are several differences in the regulation of …
Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma
Y Wu, N Yao, Y Feng, Z Tian, Y Yang… - Oncology …, 2019 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly
increased prevalence in males. The molecular mechanisms by which the inhibition or …
increased prevalence in males. The molecular mechanisms by which the inhibition or …
Sexual dimorphism in cellular and molecular features in human ACTH-secreting pituitary adenomas
F Pecori Giraldi, MF Cassarino, A Sesta, M Terreni… - Cancers, 2020 - mdpi.com
(1) Background. Cushing's disease presents gender disparities in prevalence and clinical
course. Little is known, however, about sexual dimorphism at the level of the corticotrope …
course. Little is known, however, about sexual dimorphism at the level of the corticotrope …
Effects of sex hormones on liver tumor progression and regression in Myc/xmrk double oncogene transgenic zebrafish
Hepatocellular carcinoma (HCC) shows clear sex disparity with men being more prone to
develo** HCC and having higher mortality than women. Previous studies have indicated …
develo** HCC and having higher mortality than women. Previous studies have indicated …