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Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …
on individuals and society. The development of preventive and therapeutic strategies …
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
Muscle loss during aging and disuse is a highly prevalent and disabling condition, but
knowledge about cellular pathways mediating muscle atrophy is still limited. Given the …
knowledge about cellular pathways mediating muscle atrophy is still limited. Given the …
Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining
Effects of previous strength training can be long-lived, even after prolonged subsequent
inactivity, and retraining is facilitated by a previous training episode. Traditionally, such …
inactivity, and retraining is facilitated by a previous training episode. Traditionally, such …
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness
Some of the most serious consequences of ageing are its effects on skeletal muscle. The
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …
Muscle memory and a new cellular model for muscle atrophy and hypertrophy
Memory is a process in which information is encoded, stored, and retrieved. For vertebrates,
the modern view has been that it occurs only in the brain. This review describes a cellular …
the modern view has been that it occurs only in the brain. This review describes a cellular …
Apoptotic adaptations from exercise training in skeletal and cardiac muscles
The effect of exercise on apoptosis in postmitotic tissues is not known. In this study, we
investigated the effect of regular moderate physical activity (ie, exercise training) on the …
investigated the effect of regular moderate physical activity (ie, exercise training) on the …
Catabolism of aging: is it an inflammatory process?
R Roubenoff - Current Opinion in Clinical Nutrition & Metabolic …, 2003 - journals.lww.com
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An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans
A Wikby, F Ferguson, R Forsey… - The Journals of …, 2005 - academic.oup.com
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of
high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated …
high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated …
Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants
Sarcopenia, the age-related loss of muscle mass and strength, is a fundamental cause of
frailty, functional decline and disability. In the year 2000, $18.5 billion in health care costs …
frailty, functional decline and disability. In the year 2000, $18.5 billion in health care costs …
Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy
Skeletal muscle fibres are multinucleate syncitial cells that change size during adult life
depending on functional demand. The relative contribution of change in nuclear number …
depending on functional demand. The relative contribution of change in nuclear number …