Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

Metastasis is the major driver of death in patients with cancer. Invasion of surrounding
tissues and metastasis have been proposed to initiate following loss of the intercellular …

Despite major advances in understanding the molecular and genetic basis of cancer,
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …

In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …

Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Highlights•The first step in metastasis is invasion of tumor cells into the stroma.•Stromal
collagen is dramatically remodeled during tumor progression.•Tumor cells can invade the …

Recent genomic studies challenge the conventional model that each metastasis must arise
from a single tumor cell and instead reveal that metastases can be composed of multiple …

Tumour innervation is associated with worse patient outcomes in multiple cancers,, which
suggests that it may regulate metastasis. Here we observed that highly metastatic mouse …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …