[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Regulation of endothelial cell differentiation and specification

KL Marcelo, LC Goldie, KK Hirschi - Circulation research, 2013 - Am Heart Assoc
The circulatory system is the first organ system to develop in the vertebrate embryo and is
critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of …

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

S Yan, Z Xu, F Lou, L Zhang, F Ke, J Bai, Z Liu… - Nature …, 2015 - nature.com
NF-κB is constitutively activated in psoriatic epidermis. However, how activated NF-κB
promotes keratinocyte hyperproliferation in psoriasis is largely unknown. Here we report that …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y **ng… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology

N Montenegro-Navarro, C García-Báez… - Nature …, 2023 - nature.com
Lymphangiogenesis refers to the generation of new lymphatic vessels from pre-existing
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …

Identification of miRs-143 and-145 that is associated with bone metastasis of prostate cancer and involved in the regulation of EMT

X Peng, W Guo, T Liu, X Wang, X Tu, D **ong, S Chen… - PloS one, 2011 - journals.plos.org
The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to
bone. MicroRNAs (miRNAs) play a crucial role in many tumor metastases. The importance of …

The new era of the lymphatic system: no longer secondary to the blood vascular system

I Choi, S Lee, YK Hong - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
The blood and lymphatic systems are the two major circulatory systems in our body.
Although the blood system has been studied extensively, the lymphatic system has received …

MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40

N Xu, F Meisgen, LM Butler, G Han… - The Journal of …, 2013 - journals.aai.org
Psoriasis is characterized by a specific microRNA expression profile, distinct from that of
healthy skin. MiR-31 is one of the most highly overexpressed microRNAs in psoriasis skin; …

Molecular mechanisms of neuroimmune crosstalk in the pathogenesis of stroke

YH Choi, C Laaker, M Hsu, P Cismaru… - International Journal of …, 2021 - mdpi.com
Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

The novel role of lymphatic vessels in the pathogenesis of ocular diseases

T Clahsen, K Hadrian, M Notara, SL Schlereth… - Progress in Retinal and …, 2023 - Elsevier
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent
years, however, it became evident, that lymphatic vessels or lymphatic-like vessels …