Aptamers chemistry: Chemical modifications and conjugation strategies
Soon after they were first described in 1990, aptamers were largely recognized as a new
class of biological ligands that can rival antibodies in various analytical, diagnostic, and …
class of biological ligands that can rival antibodies in various analytical, diagnostic, and …
Isothermal amplification of nucleic acids
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …
Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine
Rolling circle amplification (RCA) is an isothermal enzymatic process where a short DNA or
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …
Aptamer-based targeted protein degradation
The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays
an essential role in maintaining protein-dominated biological processes. In parallel, the …
an essential role in maintaining protein-dominated biological processes. In parallel, the …
Oligonucleotide aptamers: new tools for targeted cancer therapy
H Sun, X Zhu, PY Lu, RR Rosato, W Tan… - Molecular Therapy-Nucleic …, 2014 - cell.com
Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …
Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery
A bioinspired cocoon-like anticancer drug delivery system consisting of a
deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid …
deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid …
Aptamer-guided nanomedicines for anticancer drug delivery
Aptamers are versatile nucleic acid-based macromolecules characterized by their high
affinity and specificity to a specific target. Taking advantage of such binding properties …
affinity and specificity to a specific target. Taking advantage of such binding properties …
Aptamer-based targeted drug delivery systems: current potential and challenges
F He, N Wen, D **ao, J Yan, H **ong… - Current medicinal …, 2020 - ingentaconnect.com
Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can
specifically bind to target molecules via formed three-dimensional structures. These …
specifically bind to target molecules via formed three-dimensional structures. These …
Nucleic acid aptamers in cancer research, diagnosis and therapy
Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …
Photothermal therapeutic response of cancer cells to aptamer–gold nanoparticle-hybridized graphene oxide under NIR illumination
L Yang, YT Tseng, G Suo, L Chen, J Yu… - … applied materials & …, 2015 - ACS Publications
The objective of this study was to synthesize a nanocomposite, aptamer–gold nanoparticle-
hybridized graphene oxide (Apt-AuNP–GO), to facilitate targeted treatment of tumor cells by …
hybridized graphene oxide (Apt-AuNP–GO), to facilitate targeted treatment of tumor cells by …