Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Abstract The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in
the pineal gland and retina, and in several peripheral tissues and organs. In the circulation …

Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-kee** system. As such it regulates major physiological processes including …

Melatonin, through its different receptors, has pleiotropic functions in mammalian brain.
Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

The human pineal gland is a neuroendocrine transducer that forms an integral part of the
brain. Through the nocturnally elevated synthesis and release of the neurohormone …