Long-term outcomes of deep brain stimulation in Parkinson disease

P Limousin, T Foltynie - Nature Reviews Neurology, 2019 - nature.com
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established
for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically …

How does deep brain stimulation change the course of Parkinson's disease?

P Mahlknecht, T Foltynie, P Limousin… - Movement …, 2022 - Wiley Online Library
A robust body of evidence from randomized controlled trials has established the efficacy of
deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa‐treated …

Deep brain stimulation: a review of the open neural engineering challenges

M Vissani, IU Isaias, A Mazzoni - Journal of neural engineering, 2020 - iopscience.iop.org
Objective. Deep brain stimulation (DBS) is an established and valid therapy for a variety of
pathological conditions ranging from motor to cognitive disorders. Still, much of the DBS …

Long-term outcomes following deep brain stimulation for Parkinson's disease

FL Hitti, AG Ramayya, BJ McShane, AI Yang… - Journal of …, 2019 - thejns.org
OBJECTIVE Deep brain stimulation (DBS) is an effective treatment for several movement
disorders, including Parkinson's disease (PD). While this treatment has been available for …

Axial symptoms predict mortality in patients with Parkinson disease and subthalamic stimulation

B Lau, N Meier, G Serra, V Czernecki, M Schuepbach… - Neurology, 2019 - AAN Enterprises
Objective To characterize how disease progression is associated with mortality in a large
cohort of patients with Parkinson disease (PD) with long-term follow-up after subthalamic …

A review of cognitive outcomes across movement disorder patients undergoing deep brain stimulation

S Cernera, MS Okun, A Gunduz - Frontiers in neurology, 2019 - frontiersin.org
Introduction: Although the benefit in motor symptoms for well-selected patients with deep
brain stimulation (DBS) has been established, cognitive declines associated with DBS can …

Cognitive impact of deep brain stimulation in Parkinson's disease patients: a systematic review

V Rački, M Hero, G Rožmarić, E Papić… - Frontiers in Human …, 2022 - frontiersin.org
Introduction Parkinson's disease (PD) patients have a significantly higher risk of develo**
dementia in later disease stages, leading to severe impairments in quality of life and self …

Challenges in PD patient management after DBS: a pragmatic review

M Rossi, V Bruno, J Arena… - Movement Disorders …, 2018 - Wiley Online Library
Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or internal
globus pallidus (GPi) represents an effective and universally applied therapy for Parkinson's …

[HTML][HTML] Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease

B Freeze, D Acosta, S Pandya, Y Zhao, A Raj - NeuroImage: Clinical, 2018 - Elsevier
Multiple genes have been implicated in Parkinson disease pathogenesis, but the
relationship between regional expression of these genes and regional dysfunction across …

[HTML][HTML] Worsening of verbal fluency after deep brain stimulation in Parkinson's disease: A focused review

A Højlund, MV Petersen, KS Sridharan… - Computational and …, 2017 - Elsevier
Worsening of verbal fluency after treatment with deep brain stimulation in Parkinson's
disease patients is one of the most often reported cognitive adverse effect. The underlying …