Major depressive disorder: hypothesis, mechanism, prevention and treatment

L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - Signal transduction and …, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

Selected biomarkers of depression: what are the effects of cytokines and inflammation?

S Harsanyi, I Kupcova, L Danisovic, M Klein - International journal of …, 2022 - mdpi.com
Depression is one of the leading mental illnesses worldwide and lowers the quality of life of
many. According to WHO, about 5% of the worldwide population suffers from depression …

Immunoregulatory role of the gut microbiota in inflammatory depression

P Liu, Z Liu, J Wang, J Wang, M Gao, Y Zhang… - Nature …, 2024 - nature.com
Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the
gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an …

[HTML][HTML] Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

R Dang, M Wang, X Li, H Wang, L Liu, Q Wu… - Journal of …, 2022 - Springer
Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up

MG Mazza, M Palladini, R De Lorenzo… - Brain, behavior, and …, 2021 - Elsevier
COVID-19 outbreak is associated with mental health implications during viral infection and
at short-term follow-up. Data on psychiatric and cognitive sequelae at medium-term follow …

Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors

MG Mazza, R De Lorenzo, C Conte, S Poletti… - Brain, behavior, and …, 2020 - Elsevier
Infection-triggered perturbation of the immune system could induce psychopathology, and
psychiatric sequelae were observed after previous coronavirus outbreaks. The spreading of …

The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

COVID-19 pandemic and mental health consequences: Systematic review of the current evidence

N Vindegaard, ME Benros - Brain, behavior, and immunity, 2020 - Elsevier
Background During the COVID-19 pandemic general medical complications have received
the most attention, whereas only few studies address the potential direct effect on mental …