DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …

Introduction Biliary tract cancer represents a heterogeneous group of malignancies
characterized by dismal prognosis and scarce therapeutic options. Area covered In the last …

The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of
mortality with age, defining it as a demographically non-aging mammal. Here, we perform …

SH3 and multiple ankyrin repeat domains 1 (SHANK1) is a scaffold protein, plays an
important role in the normal function of neuron system. It has recently been shown to be a …

Background Biliary tract cancers (BTC) are rare but highly aggressive tumours with poor
prognosis, usually detected at advanced stages. Herein, we aimed at identifying BTC …

Colorectal cancer (CRC) is a major cause of cancer mortality. Early diagnosis is relevant for
its prevention and treatment. Since DNA methylation alterations are early events in …

Background DNA methylation changes, frequent early events in cancer, can modulate the
binding of transcription factors. RE1-silencing transcription factor (REST) plays a …

DNA methylation is an epigenetic process that commonly occurs in genes' promoters and
results in the transcriptional silencing of genes. DNA methylation is a frequent event in …

Colorectal cancer (CRC) is one of the most treatable cancers, but high mortality levels have
been reported as a result of its asymptomatic nature in the very early stages of the disease …

Purpose In this study, we aimed to characterize the clinical phenotype of a SHANK1-related
disorder and define the functional consequences of SHANK1 truncating variants. Methods …