RNA in cancer
GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications
K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
EMT: 2016
The significant parallels between cell plasticity during embryonic development and
carcinoma progression have helped us understand the importance of the epithelial …
carcinoma progression have helped us understand the importance of the epithelial …
MicroRNAs and cancer: Key paradigms in molecular therapy
W Tan, B Liu, S Qu, G Liang, W Luo… - Oncology …, 2018 - spandidos-publications.com
MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that performs an
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …
Epithelial-to-mesenchymal transition: epigenetic reprogramming driving cellular plasticity
N Skrypek, S Goossens, E De Smedt, N Vandamme… - Trends in Genetics, 2017 - cell.com
Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …
[HTML][HTML] The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate
protein-coding gene expression post-transcriptionally via base pairing between the 5 …
protein-coding gene expression post-transcriptionally via base pairing between the 5 …
Cancer cell plasticity: Impact on tumor progression and therapy response
V da Silva-Diz, L Lorenzo-Sanz… - Seminars in cancer …, 2018 - Elsevier
Most tumors exhibit intra-tumor heterogeneity, which is associated with disease progression
and an impaired response to therapy. Cancer cell plasticity has been proposed as being an …
and an impaired response to therapy. Cancer cell plasticity has been proposed as being an …
Breast cancer stem-like cells in drug resistance: a review of mechanisms and novel therapeutic strategies to overcome drug resistance
Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …
resistance to the available systemic therapies remains a major challenge. At the molecular …
MiR-200, a new star miRNA in human cancer
X Feng, Z Wang, R Fillmore, Y ** - Cancer letters, 2014 - Elsevier
MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene
expression at posttranscriptional/translational level. They not only play crucial roles in …
expression at posttranscriptional/translational level. They not only play crucial roles in …