Antiarrhythmic drugs for atrial fibrillation: lessons from the past and opportunities for the future
J Heijman, SH Hohnloser, AJ Camm - EP Europace, 2021 - academic.oup.com
Atrial fibrillation (AF) remains a highly prevalent and troublesome cardiac arrhythmia,
associated with substantial morbidity and mortality. Restoration and maintenance of sinus …
associated with substantial morbidity and mortality. Restoration and maintenance of sinus …
Emerging antiarrhythmic drugs for atrial fibrillation
Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex
mechanisms that differ between subgroups of patients. This complexity is apparent from the …
mechanisms that differ between subgroups of patients. This complexity is apparent from the …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial
AG Holst, J Tomcsányi, B Vestbjerg, M Grunnet… - Nature Medicine, 2024 - nature.com
Existing antiarrhythmic drugs to treat atrial fibrillation (AF) have incomplete efficacy,
contraindications and adverse effects, including proarrhythmia. AP30663, an inhibitor of the …
contraindications and adverse effects, including proarrhythmia. AP30663, an inhibitor of the …
Slow conduction corridors and pivot sites characterize the electrical remodeling in atrial fibrillation
Objectives This study aimed to evaluate the progression of electrophysiological phenomena
in a cohort of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation …
in a cohort of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation …
Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and …
E Darkow, TT Nguyen, M Stolina, FA Kari… - Frontiers in …, 2021 - frontiersin.org
In search of more efficacious and safe pharmacological treatments for atrial fibrillation (AF),
atria-selective antiarrhythmic agents have been promoted that target ion channels …
atria-selective antiarrhythmic agents have been promoted that target ion channels …
Activation of small conductance Ca2+‐activated K+ channels suppresses Ca2+ transient and action potential alternans in ventricular myocytes
G Kanaporis, LA Blatter - The Journal of physiology, 2023 - Wiley Online Library
At the cellular level, cardiac alternans is observed as beat‐to‐beat alternations in
contraction strength, action potential (AP) morphology and Ca2+ transient (CaT) amplitude …
contraction strength, action potential (AP) morphology and Ca2+ transient (CaT) amplitude …
Anti‐arrhythmic investigations in large animal models of atrial fibrillation
Atrial fibrillation (AF) constitutes an increasing health problem in the aging population.
Animal models reflecting human phenotypes are needed to understand the mechanisms of …
Animal models reflecting human phenotypes are needed to understand the mechanisms of …
Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study
By sensing changes in intracellular Ca2+, small-conductance Ca2+-activated K+ (SK)
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion
Virtual evaluation of medical therapy through human‐based modelling and simulation can
accelerate and augment clinical investigations. Treatment of the most common cardiac …
accelerate and augment clinical investigations. Treatment of the most common cardiac …