Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Background Exercise is a promising nonpharmacological therapy for cognitive dysfunction,
but it is unclear which type of exercise is most effective. The objective of this study was to …

Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …

Alzheimer's disease (AD) is a progressive neurodegenerative disease in the elderly with
dementia, memory loss, and severe cognitive impairment that imposes high medical costs …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

Hippocampal volume increase in response to aerobic exercise has been consistently
observed in animal models. However, the evidence from human studies is equivocal. We …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid β in the form of extracellular plaques and by intracellular …

Importance Early identification of cognitive impairment may improve patient and caregiver
health outcomes. Objective To systematically review the test accuracy of cognitive screening …

Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …