Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications

KR Lee, K Kim, J Jung, JH Heo, S Cho, S Lee… - Sensors, 2013 - mdpi.com
A cellular-level study of the pathophysiology is crucial for understanding the mechanisms
behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques …

Live-cell mass profiling: an emerging approach in quantitative biophysics

TA Zangle, MA Teitell - Nature methods, 2014 - nature.com
Cell mass, volume and growth rate are tightly controlled biophysical parameters in cellular
development and homeostasis, and pathological cell growth defines cancer in metazoans …

High-resolution 3D refractive index microscopy of multiple-scattering samples from intensity images

S Chowdhury, M Chen, R Eckert, D Ren, F Wu… - Optica, 2019 - opg.optica.org
Optical diffraction tomography (ODT) reconstructs a sample's volumetric refractive index (RI)
to create high-contrast, quantitative 3D visualizations of biological samples. However …

Real‐time stain‐free classification of cancer cells and blood cells using interferometric phase microscopy and machine learning

N Nissim, M Dudaie, I Barnea, NT Shaked - Cytometry Part A, 2021 - Wiley Online Library
We present a method for real‐time visualization and automatic processing for detection and
classification of untreated cancer cells in blood during stain‐free imaging flow cytometry …

Quantitative phase imaging for medical diagnosis

H Majeed, S Sridharan, M Mir, L Ma, E Min… - Journal of …, 2017 - Wiley Online Library
Optical microscopy is an indispensable diagnostic tool in modern healthcare. As a prime
example, pathologists rely exclusively on light microscopy to investigate tissue morphology …

Quantitative phase microscopy of biological samples using a portable interferometer

NT Shaked - Optics letters, 2012 - opg.optica.org
This Letter presents the τ interferometer, a portable and inexpensive device for obtaining
spatial interferograms of microscopic biological samples without the strict stability and the …

Resolution enhancement in quantitative phase microscopy

V Micó, J Zheng, J Garcia, Z Zalevsky… - Advances in Optics and …, 2019 - opg.optica.org
Quantitative phase microscopy (QPM), a technique combining phase imaging and
microscopy, enables visualization of the 3D topography in reflective samples, as well as the …

Generalized cell morphological parameters based on interferometric phase microscopy and their application to cell life cycle characterization

P Girshovitz, NT Shaked - Biomedical optics express, 2012 - opg.optica.org
We present analysis tools which are formulated using wide-field interferometric phase
microscopy measurements, and show their ability to uniquely quantify the life cycle of live …

Measurement of Single Cell Refractive Index, Dry Mass, Volume, and Density<? format?> Using a Transillumination Microscope

KG Phillips, SL Jacques, OJT McCarty - Physical review letters, 2012 - APS
Phase contrast microscopy has become ubiquitous in the field of biology, particularly in
qualitative investigations of cellular morphology. However, the use of quantitative phase …

Quantitative refractive index distribution of single cell by combining phase-shifting interferometry and AFM imaging

Q Zhang, L Zhong, P Tang, Y Yuan, S Liu, J Tian… - Scientific reports, 2017 - nature.com
Cell refractive index, an intrinsic optical parameter, is closely correlated with the intracellular
mass and concentration. By combining optical phase-shifting interferometry (PSI) and atomic …