Interplay of immune modulation, adaptive response and hormesis: Suggestive of threshold for clinical manifestation of effects of ionizing radiation at low doses?

RK Chaurasia, BK Sapra, DK Aswal - Science of the Total Environment, 2024‏ - Elsevier
The health impacts of low-dose ionizing radiation exposures have been a subject of debate
over the last three to four decades. While there has been enough evidence of “no adverse …

External environmental agents influence telomere length and telomerase activity by modulating internal cellular processes: Implications in human aging

SG Fernandes, R Dsouza, E Khattar - Environmental Toxicology and …, 2021‏ - Elsevier
External environment affects cellular physiological processes and impact the stability of our
genome. The most important structural components of our linear chromosomes which …

Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious

A Porrazzo, F Cipressa, A De Gregorio… - Communications …, 2022‏ - nature.com
It is still continuously debated whether the low-dose/dose-rate (LDR) of ionizing radiation
represents a hazard for humans. Model organisms, such as fruit flies, are considered …

Environmental pollutants exposure: A potential contributor for aging and age-related diseases

Y Liu, J Wang, Z Huang, J Liang, Q **a, Q **a… - Environmental …, 2021‏ - Elsevier
Telomeres are “protective messengers” at the ends of eukaryotic chromosomes that protect
them from degradation, end to end fusion and recombination. Admittedly, telomeres …

Evaluation of natural chronic low dose radiation exposure on telomere length and transcriptional response of shelterin complex in individuals residing in Kerala coast …

D Saini, V Jain, B Das - Mutation Research/Fundamental and Molecular …, 2022‏ - Elsevier
The high level natural radiation areas (HLNRA) of Kerala coast provide unique opportunity
to study the biological effect of chronic low dose ionizing radiation (LDIR) on human …

Functional analysis of polymorphism haplotypes of MGMT in residents of high background radiation area

L Zhou, S Zhang, WX Huang, L Zhang, Y Cai… - …, 2023‏ - academic.oup.com
To investigate the distribution of polymorphisms and their frequent haplotypes in the
regulatory region of MGMT in residents of high background radiation area (HBRA) and their …

[HTML][HTML] Space Medicine: Why Do Recently Published Papers about Telomere Length Alterations Increase our Uncertainty Rather than Reduce it?

JJ Bevelacqua, J Welsh, SAR Mortazavi… - Journal of …, 2021‏ - pmc.ncbi.nlm.nih.gov
There is a growing interest in examining alterations in telomere length as a reliable
biomarker of general health, as well as a marker for predicting later morbidity and mortality …

Changes in Telomere Length in Leukocytes and Leukemic Cells after Ultrashort Electron Beam Radiation

T Harutyunyan, A Sargsyan, L Kalashyan… - International journal of …, 2024‏ - mdpi.com
Application of laser-generated electron beams in radiotherapy is a recent development.
Accordingly, mechanisms of biological response to radiation damage need to be …

Ramsar, Iran, as a Natural Radiobiological Surrogate for Mars

JS Welsh, JJ Bevelacqua, SMJ Mortazavi - Health Physics, 2022‏ - journals.lww.com
Terrestrial experiments involving acute exposures of low-LET radiation on inbred lab
animals are quick, simple, and inexpensive but are relatively uninformative about the real …

Telomere fragility in radiology workers occupationally exposed to low doses of ionising radiation

J Filipović Tričković, A Valenta Šobot, I Joksić… - Arhiv za higijenu rada i …, 2022‏ - hrcak.srce.hr
Sažetak Ionising radiation damages DNA directly and indirectly through increased
production of reactive oxygen species. Although telomeres have been reported as indicators …