The first animal mitochondrial genomes to be sequenced were of several vertebrates and
model organisms, and the consistency of genomic features found has led to a 'textbook …

Mitochondria are energy factories of cells and are important pivots for intracellular
interactions with other organelles. They interact with the endoplasmic reticulum …

The partitioning of genetic material between the nucleus and cytoplasmic (mitochondrial and
plastid) genomes within eukaryotic cells necessitates coordinated integration between these …

Metazoans exist only with a continuous and rich supply of chemical energy from oxidative
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …

Mitochondria, a nearly ubiquitous feature of eukaryotes, are derived from an ancient
symbiosis. Despite billions of years of cooperative coevolution—in what is arguably the most …

Recent advances in long-read sequencing technology have allowed for single-molecule
sequencing of entire mitochondrial genomes, opening the door for direct investigation of the …

Genetic elements encoded in nuclear DNA determine the sex of an individual in many
animals. In certain bivalve lineages that possess doubly uniparental inheritance (DUI) …

Heteroplasmy is the presence of more than one type of mitochondrial genome within an
individual, a condition commonly reported as unfavorable and affecting mitonuclear …

Mitochondrial sequence variants affect phenotypic function, often through interaction with
the nuclear genome. These “mitonuclear” interactions have been linked both to evolutionary …

The mitonuclear genome is the most successful co-evolved mutualism in the history of life on
Earth. The cross-talk between the mitochondrial and nuclear genomes has been shaped by …