Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
Measuring and interpreting transposable element expression
Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response
T cells mediate antigen-specific immune responses to disease through the specificity and
diversity of their clonotypic T cell receptors (TCRs). Determining the spatial distributions of T …
diversity of their clonotypic T cell receptors (TCRs). Determining the spatial distributions of T …
Mammalian genome innovation through transposon domestication
Since the discovery of transposons, their sheer abundance in host genomes has puzzled
many. While historically viewed as largely harmless 'parasitic'DNAs during evolution …
many. While historically viewed as largely harmless 'parasitic'DNAs during evolution …
Epigenetic priming enhances antitumor immunity in platinum-resistant ovarian cancer
Background Immune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer
(OC). To augment their activity, we used priming with the hypomethylating agent …
(OC). To augment their activity, we used priming with the hypomethylating agent …
Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues
Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in
cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA …
cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA …
The dynamism of transposon methylation for plant development and stress adaptation
Plant development processes are regulated by epigenetic alterations that shape nuclear
structure, gene expression, and phenotypic plasticity; these alterations can provide the plant …
structure, gene expression, and phenotypic plasticity; these alterations can provide the plant …
Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression
There is considerable interest in understanding the effect of transposable elements (TEs) on
embryonic development. Studies in humans and mice are limited by the difficulty of working …
embryonic development. Studies in humans and mice are limited by the difficulty of working …
Histone methyltransferase activity affects metabolism in human cells independently of transcriptional regulation
The N-terminal tails of eukaryotic histones are frequently posttranslationally modified. The
role of these modifications in transcriptional regulation is well-documented. However, the …
role of these modifications in transcriptional regulation is well-documented. However, the …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …