Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for
about a quarter of adult acute leukemias, and features different outcomes depending on the …

Ultra-deep next-generation sequencing has emerged in recent years as an important
diagnostic tool for the detection and follow-up of tumor burden in most of the known …

Assessment of clonality, marker identification and measurement of minimal residual disease
(MRD) of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in lymphoid …

Background The B and T lymphocytes are white blood cells playing a key role in the
adaptive immunity. A part of their DNA, called the V (D) J recombinations, is specific to each …

Simple Summary Minimal/measurable residual disease (MRD) monitoring is a powerful and
independent predictor of outcomes in both children and adult acute lymphoblastic leukemia …

While the prognostic role of immunoglobulin heavy chain locus (IGH) rearrangement in
minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has …

Minimal residual disease (MRD) monitoring has proven to be one of the fundamental
independent prognostic factors for patients with acute lymphoblastic leukemia (ALL) …

Antigen receptor gene rearrangements are frequently applied as molecular targets for
detection of minimal residual disease (MRD) in B-cell precursor acute lymphoblastic …

Background Assessment of measurable residual disease (MRD) is an essential prognostic
tool for B-lymphoblastic leukaemia (B-ALL). In this study, we evaluated the utility of next …

Background Next-generation sequencing (NGS) of the rearranged immunoglobulin heavy-
chain gene has emerged as a highly sensitive method to detect minimal residual disease …