Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Point of care testing for infectious diseases
Infectious diseases are caused by pathogenic microorganisms and can be transmitted
between individuals and populations thus threatening the general public health and …
between individuals and populations thus threatening the general public health and …
Monocyte-derived macrophages contain persistent latent HIV reservoirs
RT Veenhuis, CM Abreu, PAG Costa, EA Ferreira… - Nature …, 2023 - nature.com
The development of persistent cellular reservoirs of latent human immunodeficiency virus
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape
Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties
of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 …
of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 …
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure,–.
Curative strategies that target the reservoir are being tested, and require accurate, scalable …
Curative strategies that target the reservoir are being tested, and require accurate, scalable …
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
NN Hosmane, KJ Kwon, KM Bruner… - Journal of Experimental …, 2017 - rupress.org
A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
F Maldarelli, X Wu, L Su, FR Simonetti, W Shao, S Hill… - Science, 2014 - science.org
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
Pathophysiology of CD4+ T-cell depletion in HIV-1 and HIV-2 infections
The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
Origins of HIV and the AIDS pandemic
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response
To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The
number of clinical trials that can be performed is limited. We developed mathematical …
number of clinical trials that can be performed is limited. We developed mathematical …